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Juan Miguel Rivera Dia's avatar

D-glucose isn't the only metabolizable sugar in formose. Among the D sugars there's glyceraldehyde, ribose, xylose, ribulose, xylulose, mannose, galactose, fructose, tagatose, and sedoheptulose, plus possibly allose, altrose, and talose. Among the L sugars there's glyceraldehyde, xylose, xylulose, gulose, galactose (extremely poorly though), psicose, and sorbose (though it's also a toxic compound), plus possibly allose, altrose, idose, and talose. Dihydroxyacetone can also be metabolized, as can glycerol, glyceric acid, allitol, DL-altritol, D-sorbitol, D-mannitol, galactitol (very poorly), D-gluconic acid, L-gulonic acid, D-galactonic acid, L-iditol, and possibly ribitol, DL-arabinitol, L-galactonic acid, and L-idonic acid. The other aldoses can also potentially contribute energy by way of aldehyde dehydrogenase, but they could also sap antioxidant defenses via aldose reductase. Another way would be via bacterial fermentation in the gut (which generates short-chain fatty acids that can be absorbed). Branched-chain sugars would be the most troublesome of the bunch, as only D-apiose and D-hamamelose are known to be metabolized by bacteria or any other organism. As for formose as a whole, studies have shown that amounts above 20% of the diet killed subject animals (very possibly through a combination of severe diarrhea, antioxidant depletion, osmotic stress, glycation stress, high anion gap acidosis, and phosphate trapping), with purified formose enabling longer survival compared to crude formose, and amounts above 10% impaired weight gain.

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Juan Miguel Rivera Dia's avatar

An addendum: under some conditions formose can include C9 sugars, and some of formose's toxicity could be caused by non-metabolizable C7, C8, and C9 sugars; D-mannoheptulose is known to inhibit glycolysis and insulin secretion.

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